Zagazig is a city in Lower Egypt. Situated in the eastern part of the Nile delta, it is the capital of the governorate of Sharqia.

In 1999, its population was approximately 279,000, which increased to 302,611 in 2006. It is built on a branch of the Sweet Water Canal and on al-Muˤizz Canal (the ancient Tanaitic channel of the Nile), and is 47 miles by rail north-northeast of Cairo. Situated on the Nile Delta in the midst of a fertile district, Zagazig is a centre of the cotton and grain trade of Egypt. It has large cotton factories and used to have offices of numerous European merchants.

It is located on the Muweis Canal and is the chief hub of the corn and cotton trade. There is a museum of antiquities, the Sharkeya National Museum (sometimes called the Amed Orabi Museum, at Herriat Raznah) that contains many important archaeological exhibits (currently closed for restoration).

Zagazig University, one of the largest universities in Egypt, is also located in the city, with colleges in different fields of science and arts. The Archaeological Museum of the University of Zagazig exhibits significant finds from the nearby sites, Bubastis (Tell Basta) and Kufur Nigm. Also there is a branch for Al-Azhar University, the largest Islamic university in the world.

Zagazig is the birthplace of famous Coptic Egyptian journalist, philosopher and social critic, Salama Moussa.